Detection of hepatitis C virus RNA in saliva is not related to oral health status or viral load
Identifieur interne : 000242 ( France/Analysis ); précédent : 000241; suivant : 000243Detection of hepatitis C virus RNA in saliva is not related to oral health status or viral load
Auteurs : Liliane Lins [Brésil] ; Herbert Almeida [Brésil] ; Ludmila Vitvisk [France] ; Theomira Carmo [Brésil] ; Raymundo Paraná [Brésil] ; Mitermayer G. Reis [Brésil]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2005-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Anatomic pathology, Chronic hepatitis, Chronic liver disease, Cooperation program, Dental caries, Dental disease, Dental status, Dental surgeries, Dentate, Detection, Disposable equipment, Genotype, Grant number, Grant sponsor, Hcvrna detection, Hepatitis, Hepatitis C virus, Human saliva, Lichen planus, Liver transplantation, Mucosal lesions, Negative control, Negative control group, Oral examination, Oral health, Oral lichen planus, Oral pathology, Oral surgery, Parenteral exposure, Parenteral route, Periodontal, Periodontal disease, Polymerase chain reaction, Positive group, Positive individuals, Positive patients, Saliva, Saliva samples, Salivary glands, Serum samples, Serum transudation, Viral, Viral hepatitis C, Viral load, Virol, Virus infection, Virus liver disease, Whole saliva.
- Teeft :
- Chronic hepatitis, Chronic liver disease, Cooperation program, Dental caries, Dental status, Dental surgeries, Dentate, Disposable equipment, Genotype, Grant number, Grant sponsor, Hcvrna detection, Hepatitis, Human saliva, Lichen planus, Liver transplantation, Mucosal lesions, Negative control, Negative control group, Oral examination, Oral health, Oral lichen planus, Oral pathology, Oral surgery, Parenteral exposure, Parenteral route, Periodontal, Periodontal disease, Polymerase chain reaction, Positive group, Positive individuals, Positive patients, Saliva, Saliva samples, Salivary glands, Serum samples, Serum transudation, Viral, Viral load, Virol, Virus infection, Virus liver disease, Whole saliva.
Abstract
Hepatitis C is a worldwide public health problem and its transmission is clearly associated with the parenteral route, however, the virus has also been isolated from other body fluids. Hepatitis C virus (HCV) RNA has been detected in saliva, yet the relationship between HCV and oral pathology is not clearly understood. Therefore, an investigation on HCV‐RNA in saliva and its correlation with oral pathology was undertaken. Saliva and blood samples were collected from 50 anti‐HCV positive patients and from 25 patients with non‐HCV chronic liver disease. HCV‐RNA was detected in all of the saliva samples from the HCV positive group. None of the saliva or serum samples from the non‐HCV group were positive for HCV‐RNA. The patients were examined for dental and oral health (dentate, partially dentate, edentulous, evidence of gum disease, or mucosal lesions); however, no correlation was found between HCV‐RNA in saliva, oral health, and viral load. These results suggest that HCV‐RNA presence in saliva is independent of the viral load and the oral pathology of HCV positive individuals. J. Med. Virol. 77:216–220, 2005. © 2005 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.20438
Affiliations:
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Waldemar Falcão, 121‐ Brotas, 40.295.001. Salvador, Bahia</wicri:regionArea><placeName><region type="state">Bahia</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">77</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="216">216</biblScope><biblScope unit="page" to="220">220</biblScope><biblScope unit="page-count">5</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-10">2005-10</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anatomic pathology</term><term>Chronic hepatitis</term><term>Chronic liver disease</term><term>Cooperation program</term><term>Dental caries</term><term>Dental disease</term><term>Dental status</term><term>Dental surgeries</term><term>Dentate</term><term>Detection</term><term>Disposable equipment</term><term>Genotype</term><term>Grant number</term><term>Grant sponsor</term><term>Hcvrna detection</term><term>Hepatitis</term><term>Hepatitis C virus</term><term>Human saliva</term><term>Lichen planus</term><term>Liver transplantation</term><term>Mucosal lesions</term><term>Negative control</term><term>Negative control group</term><term>Oral examination</term><term>Oral health</term><term>Oral lichen planus</term><term>Oral pathology</term><term>Oral surgery</term><term>Parenteral exposure</term><term>Parenteral route</term><term>Periodontal</term><term>Periodontal disease</term><term>Polymerase chain reaction</term><term>Positive group</term><term>Positive individuals</term><term>Positive patients</term><term>Saliva</term><term>Saliva samples</term><term>Salivary glands</term><term>Serum samples</term><term>Serum transudation</term><term>Viral</term><term>Viral hepatitis C</term><term>Viral load</term><term>Virol</term><term>Virus infection</term><term>Virus liver disease</term><term>Whole saliva</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anatomopathologie</term><term>Charge virale</term><term>Dent pathologie</term><term>Détection</term><term>Hépatite virale C</term><term>Salive</term><term>Virus hépatite C</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Chronic hepatitis</term><term>Chronic liver disease</term><term>Cooperation program</term><term>Dental caries</term><term>Dental status</term><term>Dental surgeries</term><term>Dentate</term><term>Disposable equipment</term><term>Genotype</term><term>Grant number</term><term>Grant sponsor</term><term>Hcvrna detection</term><term>Hepatitis</term><term>Human saliva</term><term>Lichen planus</term><term>Liver transplantation</term><term>Mucosal lesions</term><term>Negative control</term><term>Negative control group</term><term>Oral examination</term><term>Oral health</term><term>Oral lichen planus</term><term>Oral pathology</term><term>Oral surgery</term><term>Parenteral exposure</term><term>Parenteral route</term><term>Periodontal</term><term>Periodontal disease</term><term>Polymerase chain reaction</term><term>Positive group</term><term>Positive individuals</term><term>Positive patients</term><term>Saliva</term><term>Saliva samples</term><term>Salivary glands</term><term>Serum samples</term><term>Serum transudation</term><term>Viral</term><term>Viral load</term><term>Virol</term><term>Virus infection</term><term>Virus liver disease</term><term>Whole saliva</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hepatitis C is a worldwide public health problem and its transmission is clearly associated with the parenteral route, however, the virus has also been isolated from other body fluids. Hepatitis C virus (HCV) RNA has been detected in saliva, yet the relationship between HCV and oral pathology is not clearly understood. Therefore, an investigation on HCV‐RNA in saliva and its correlation with oral pathology was undertaken. Saliva and blood samples were collected from 50 anti‐HCV positive patients and from 25 patients with non‐HCV chronic liver disease. HCV‐RNA was detected in all of the saliva samples from the HCV positive group. None of the saliva or serum samples from the non‐HCV group were positive for HCV‐RNA. The patients were examined for dental and oral health (dentate, partially dentate, edentulous, evidence of gum disease, or mucosal lesions); however, no correlation was found between HCV‐RNA in saliva, oral health, and viral load. These results suggest that HCV‐RNA presence in saliva is independent of the viral load and the oral pathology of HCV positive individuals. J. Med. Virol. 77:216–220, 2005. © 2005 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Bahia</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="Brésil"><region name="Bahia"><name sortKey="Lins, Liliane" sort="Lins, Liliane" uniqKey="Lins L" first="Liliane" last="Lins">Liliane Lins</name></region><name sortKey="Almeida, Herbert" sort="Almeida, Herbert" uniqKey="Almeida H" first="Herbert" last="Almeida">Herbert Almeida</name><name sortKey="Carmo, Theomira" sort="Carmo, Theomira" uniqKey="Carmo T" first="Theomira" last="Carmo">Theomira Carmo</name><name sortKey="Carmo, Theomira" sort="Carmo, Theomira" uniqKey="Carmo T" first="Theomira" last="Carmo">Theomira Carmo</name><name sortKey="Lins, Liliane" sort="Lins, Liliane" uniqKey="Lins L" first="Liliane" last="Lins">Liliane Lins</name><name sortKey="Parana, Raymundo" sort="Parana, Raymundo" uniqKey="Parana R" first="Raymundo" last="Paraná">Raymundo Paraná</name><name sortKey="Reis, Mitermayer G" sort="Reis, Mitermayer G" uniqKey="Reis M" first="Mitermayer G." last="Reis">Mitermayer G. Reis</name><name sortKey="Reis, Mitermayer G" sort="Reis, Mitermayer G" uniqKey="Reis M" first="Mitermayer G." last="Reis">Mitermayer G. Reis</name><name sortKey="Reis, Mitermayer G" sort="Reis, Mitermayer G" uniqKey="Reis M" first="Mitermayer G." last="Reis">Mitermayer G. Reis</name><name sortKey="Reis, Mitermayer G" sort="Reis, Mitermayer G" uniqKey="Reis M" first="Mitermayer G." last="Reis">Mitermayer G. Reis</name><name sortKey="Reis, Mitermayer G" sort="Reis, Mitermayer G" uniqKey="Reis M" first="Mitermayer G." last="Reis">Mitermayer G. Reis</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Vitvisk, Ludmila" sort="Vitvisk, Ludmila" uniqKey="Vitvisk L" first="Ludmila" last="Vitvisk">Ludmila Vitvisk</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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